Matakana Fisetin Ultra, with Fenugreek and Fucoidan
Supports: Healthy aging; Immune System and metabolic health.
A build-up of senescent cells is considered to be one of the 9 Hallmarks of Ageing. Targeting senescent cells with senolytics may support health & wellbeing as we age.
Senolytics are compounds that support the body’s natural ability to clear old, damaged (senescent) cells to make way for new, healthy cells. Fisetin, a flavonoid found in various plants and in minute quantities in some fruits and vegetables, is one of the most powerful natural senolytics ever discovered.
What is Cellular Senescence?
Cellular senescence is a phenomenon where cells cease to divide but remain metabolically active. This means they are still 'alive' and growing, generating energy, and creating and eliminating waste. Senescent cells are usually enlarged due to their growth in the absence of division. These senescent cells are sometimes referred to as zombie cells – no longer functioning normally and creating havoc wherever they're found in the body.
These zombie cells secrete numerous pro-inflammatory and proteolytic factors (enzymes that break down protein), marked by the secretion of proinflammatory cytokines. Senescent cells have been shown to accumulate with age, a phenomenon that impedes innate and adaptive immune responses. Common cellular stressors such as; oxidative stress, DNA damage and mitochondrial dysfunction can trigger cellular senescence in cells. Because senescent cells remain metabolically active, the burden of senescent cells within the body increases, altering the local microenvironment, tissue structure and function.
Supplementation with senolytic compounds such as Fisetin, which supports the body's normal targeting of senescent cells, is emerging as a viable approach to support the body’s natural removal of senescent cells. Fisetin is the main ingredient in our Fisetin+.
Who might benefit?
Under 30 years: Intermittently as directed by your health care professional or if you have been ill or have metabolic issues.
30 years+: One week every quarter (i.e. four weeks per year) or as directed by your health care professional.
40 years+: Six (6) weeks per year (i.e. one week every second month) or as directed by your health care professional.
50 years+: One week per month or as directed by your health care professional Dosage: One capsule morning and night for seven consecutive days (i.e.14 capsules per week).
Why not take a senolytic daily?
Research has shown they are effective when taken intermittently so in most cases it is not necessary to take them daily unless advised by your health care professional.
Each capsule contains:
Fisetin - 400mg
Fucoidan - 100mg
Fenugreek with 35% galactomannans - 83mg
Other ingredients: cellulose (veg cap), magnesium stearate (tableting aid).